attana - sensor technologies

Accessibility

An association rate difference between biochemical and cell-based assays indicates the accessibility of the receptor and can easily be measured with the Attana cell-based biosensor.

The success rate in the design and discovery of new therapeutic compounds will increase if the biologically relevant environment is enhanced. Studying target interactions in their native environment, in-situ, only candidates with biologically relevant properties will be selected for downstream applications.

A therapeutic candidate needs to reach its target without too much hindrance to be successful. On the cell surfaces, there’re i.e. carbohydrates which can hinder antibody binding to its target by sterical hindrance. The accessibility of a drug candidate to its target is of high importance to study, it doesn’t matter how good a drug candidate is by itself, if it doesn’t reach its target. An incubation method doesn’t give this information, while an instrument with a continuous-flow does. In addition, labeling of the drug candidate can affect the binding as well by hindrance of the accessibility. The Attana instruments have both a continuous-flow and no need of labeling, allowing studying the drug candidate interactions directly to the cell surface to obtain a surrounding as close as possible to the in vivo environment within the biosensor, giving the valuable information about the accessibility.

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