attana - sensor technologies

Peptide receptor interactions in a cellular environment

Publication of a label-free assay characterizing interactions between peptides and their target receptors in a cellular environment,

The drug development process as well as fundamental studies of mechanisms’ underlying biological interactions require analytical methods that approximate the in vivo situation as much as possible. Attana instruments are featured in a publication presenting a new label-free assay developed to characterize interactions between peptides and their target receptors in a cellular environment. It describes one interaction that was assessed by monitoring the binding profile in real-time and by quantifying its kinetic rate constants for association and dissociation, as well as its affinity. In addition, the absence of off-target interactions with the cell membrane was confirmed by analysis of the binding profile.

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