attana - sensor technologies

Pharmacodynamics

To obtain information about the underlying biochemical and physiological effects of the pharmacodynamics, PD, it is crucial to measure the full binding profile of the drug-receptor interaction, which can easily be done with all Attana systems.

PD is the biochemical and physiological effects that a pharmaceutical drug has in the body, the mechanism of action (MOA). Experimentally, the PD can be measured as the drug concentration and its effect.

In the Attana system this can be measured by a kinetic experiment. L + R ↔LR, where L=ligand (drug), R=receptor (allosteric site). All Attana systems can measure the biochemical kinetics of the drug-receptor interaction and the Attana Cell 200 can measure in cell-based assay providing information on accessibility of receptors and off target interactions of the pharmaceutical drug.