attana - sensor technologies

Surface chemistry development

To obtain the full binding kinetics of a modified chemical composition of a surface to its ligand it is important to fully understand the interaction to be studied within the surface chemistry development process. This can be done with Attana biosensors. 

Surface chemistry deals with the study of chemical phenomena that occur at the surfaces or interfaces of two substances, usually between a gas and a solid or between a liquid and a solid. It aims at modifying the chemical composition of a surface by incorporation of functional groups that produce various effects or improvements in the properties of the surface or interface.

Most surface chemistry processes involve the interaction of surfaces of one system with the particles of another system/systems. The subject of surface chemistry finds many applications in analytical work. Biosensors consist of a physicochemical transducer in direct contact with a biological recognition element such as antibodies, cells, neurons and so on. Surface chemistry is used to link both elements. The unique surface chemistry for enhanced biosensor performance allows a highly specific interaction of the analyte with the immobilized molecules.

All Attana systems offer the possibility to modify the sensor surface to introduce new functional groups, extending the range of chemistries that can be used for immobilization. By modifying the sensor surface, a wide versatility of chips can be engineered and produced for different applications. Examples of this are Polystyrene sensor chip, Silicon Dioxide sensor chip, Gold sensor chip, LNB Carboxyl sensor chip, Biotin sensor chip, COP-1 sensor chip, Carboxyl sensor chip. The Polystyrene sensor chip is designed to allow ex situ immobilization. The Silicon Dioxide sensor chip is used in basic research and possible customization of complimentary surfaces in different applications. The Gold sensor chip is used in basic research and possible customization of complimentary surfaces in different applications. The LNB Carboxyl sensor chip offers low non-specific binding and is the most widely used and versatile surface for molecular interaction studies and can be used for His-tag chemistry. The Biotin sensor chip is used when biotinylated molecules are available. The COP-1 sensor chip enables the growth of mammalian cells onto the surface. The Carboxyl sensor chip is used for the same molecular interaction studies as the LNB sensor chip. By immobilizing a target molecule to the sensor surface, the interaction between the target molecule and another molecule flowing over the surface can be studied in real time. The advantage with the sensor chip is that it provides versatile functionality and performance for different applications.